In the field of innovative galenic formulation, Octalia has developed a process for phospholipid based formula leading to a fine dispersion prepared without using heat or organic solvent and which can be sterilized by filtration. Such formulas could considerably help solubilization and bioavailability of poorly soluble drugs and improve stability. Examination by electronic transmission microscopy highlights high proportion of particles close to nanometers size; biggest being around 50nm.

This technology may be envisaged as vehicle for hydrophilic or hydrophobic active molecules in particular for ophthalmology, dermatology and cosmetic.

Feel free to contact Octalia Technologies to see further.

Ophtalmic compositions containing a nitric oxide releasing prostamide

Pilotaz F., Weiner A.L., Do M., Saldo J.

Carrier in oil-in-water emulsion form, particularly for cosmetic or dermatological use

Boix M., Do M., Sarrazin C.

Vehicle in the form of a oil-in-water emulsion in particular for ophthalmic or dermocosmetic use

Boix M., Do M., Sarrazin C.

Forming biocidal support surface, useful as preservative e.g. for cosmetic, comprises fixing polymer layer and polymerization initiator on activated support surface, forming another polymer layer and optionally fixing biocidal agent

Géribaldi S., Guittard F., Guittard E., Soufi A., Sarrazin C., Do M., Boix M., Foucher L., Labbe J.

Dendrimer-drug conjugates

Gingras M., Raimundo J-M., Chabre Y., Boix M., Do M., Sarrazin C., Delayahe L.

Method of sterilization by irradiation of polymeric materials suitable for therapeutical purposes

Michèle Boix, Christian Sarrazin, Patrick M. Hughes, Marina Do, Isabelle Maroteaux

Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component

Patrick M. hughes, Michèle Boix, Laurent Delayahe

Retinoid-containing sustained release intraocular drug delivery systems and related methods

Patrick M. Hughes, Orest Olejnik, Glenn T. Huang, Joan-En Chang-Lin, Thierry Nivaggioli, Jane Gui Shiah, Michèle Boix, Christian Sarrazin

Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods

Patrick M. Hughes, Laurent Delahaye, Michèle Boix, James N. Chang, Robert T. Lyons

Method for producing preparation of biodegradable microspheres

Patrick M. Hughes, Christian Sarrazin, Elisabeth Rossi, Michèle Boix

Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods

Patrick M. Hughes, Michèle Boix, Christian Sarrazin, Marina Do

Study of Xailin Night physical properties versus marketed ocular lubricant products

Pilotaz F., Saldo J., Boix M., Octobre 2015, Ever (poster communication); Nice (France)

Study of Xailin HA physical properties versus marketed ocular lubricant products

Pilotaz F., Pecout A., Do M., Octobre 2015, Ever (poster communication), Nice (France)

Formulation en ophtalmologie

Boix M., Septembre 2012, 2ème Rencontre Eurobiomed-Ophtabiotech, Montpellier (France)

Beta adrenergic binding sites in the human eye: an autoradiographic study

Elena PP, Denis P, Kosina-Boix M, Saraux H, Lapalus P.

J Ocul Pharmacol. 1990 Summer;6(2):143-9

Dopamine receptors in rabbit and rat eye: characterization and localization of DA1 and DA2 binding sites

Elena PP, Denis P, Kosina-Boix M, Lapalus P

Curr Eye Res. 1989 Jan;8(1):75-83

Alpha2-adrenergic receptors in rat and rabbit eye: a tritium-sensitive film autoradiography

Elena PP, Kosina-Boix M, Denis P, Moulin G, Lapalus P

Ophthalmic Res. 1989;21(4):309-14

Autoradiographic localization of beta-adrenergic receptors in rabbit eye

Elena PP, Kosina-Boix M, Moulin G, Lapalus P

Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1436-41